The ICREAs

ICREA research professors form a vibrant community of scientists and researchers in all areas of knowledge that contribute to the advancement of humankind by exploring, interpreting and questioning. Have a look and learn about their amazing discoveries and findings here:

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    De Fabritiis, Gianni
    Research Professor at
    Universitat Pompeu Fabra (UPF)
    Experimental Sciences & Mathematics
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    Research interests

    Prof. Gianni De Fabritiis leads the computational science laboratory whose  interests are the application of computation to solve real world problems, where we define intelligence as a form of computation. The research group develops machine learning models with intelligent, useful behavior using reinforcement learning and deep learning, for specific environments. Biomedicine is one environment where physics-based simulations and machine learning to provide novel, innovative approaches. The group leads GPUGRID.net, one of the top  distributed computing projects worldwide for running molecular simulations on GPUs and the open platform PlayMolecule.org that has around a thousand registered scientists. The group and its spin-off company Acellera have collaborated with major industries worldwide like Sony, Nvidia, HTC mobile, UCB, Pfizer, Biogen and Novartis.

    Key words

    computational biophysics, drug discovery, molecular kinetics, molecular simulations, accelerated and distributed computing
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    de Graaf, Coen
    Research Professor at
    Universitat Rovira i Virgili (URV)
    Experimental Sciences & Mathematics
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    Research interests

    Changing properties of materials by shining light on it is an interesting phenomenon. It becomes even more exciting when the initial state can be repopulated by irradiation with light of different wave length. The material becomes then switchable and technological applications appear at the horizon. Insight in the mechanisms of light-induced properties may eventually lead to new materials. We apply techniques from computational chemistry to obtain information about the light-induced electronic state and the deactivation to the final state. The interplay between the electronic structure and the movement of the nuclei plays an important role in the deactivation. We aim to go beyond the traditional static description by introducing the dynamics of the nuclear movement and obtain a more complete picture of the switching mechanism.

    Key words

    Theoretical Chemistry; Transition metal compounds; Light induced magnetism

    ORCID

    : http://orcid.org/0000-0001-8114-6658

    RESEARCHER ID

    : A-5677-2008
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    de la Cruz Montserrat, Francisco Javier
    Research Professor at
    Vall d'Hebron Institut de Recerca (VHIR)
    Life & Medical Sciences
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    Research interests

    Our main research aims at understanding the molecular basis of hereditary disease, integrating two complementary aspects: the molecular impact of causative variants and how genetic background regulates the propagation of this impact. At a technical level, to reach our objective, we integrate the results of the most advanced genomic experiments (single-cell, Hi-C, etc.) using state-of-the-art machine learning tools. To enhance the biomedical reach of our research, we work in collaboration with clinical groups from different hospitals. As a result of these efforts, we have recently made significant advances in understanding the functional effect of BRCA1/2 protein variants underlying hereditary breast and ovarian cancers. Finally, mention that we are also devoting an important part of our efforts to the fundamental study of epigenetic processes, to reach a full picture of which phenomena contribute to the generation of phenotype and, more precisely, of clinical phenotype. 

    Key words

    Computational Biology, In silico tools, Protein Mutations, Molecular Diagnostics, Bioinformatics, Epigenetics, Systems Biology

    ORCID

    : 0000-0002-9738-8472
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    de la Luna Gargantilla, Susana
    Research Professor at
    Centre de Regulació Genòmica (CRG)
    Life & Medical Sciences
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    Research interests

    Protein kinases are central to all cellular processes in eukaryotes, and often linked to disease when they are altered. My group works on a family of protein kinases known as DYRK (dual-specificity tyrosine-regulated kinases), whose members -DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4- participate in the regulation of processes critical for cellular viability and homeostasis, and their dysregulation leads to disease in humans. Thus, DYRK1A overexpression in Down syndrome (DS) correlates with several DS pathological phenotypes. Moreover, mutations in one DYRK1A allele are associated with general growth retardation and microcephaly, defining a rare syndrome. DYRK1A alterations are also associated to tumor progression. My group aims at dissecting how DYRK activities are linked to human pathology. We are particularly interested on the DYRK-associated activities that impact on the regulation of expression programs either directly on chromatin or indirectly through modulation of signaling pathways.

    Key words

    cell signaling, protein kinases, transcriptional regulation, DYRK kinases, Down syndrome

    ORCID

    : orcid.org/0000-0001-7765-916X

    RESEARCHER ID

    : E-9553-2015
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    de Riedmatten, Hugues
    Research Professor at
    Institut de Ciències Fotòniques (ICFO)
    Engineering Sciences
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    Research interests

    Hugues de Riedmatten leads the Quantum Photonics group at ICFO. His research interests are in quantum information science (QIS) and quantum optics. QIS is a research field that aims at controlling quantum coherence in light and matter in order to enable new information processing capabilities impossible with classical resources. He is interested in the quantum control of light matter interaction between single photons and atomic ensembles implemented with rare-earth doped solids and cold atomic gases. Other research lines include quantum non-linear optics with Rydberg atoms, and the detection and manipulation of single ions in the solid-state. The goal is to develop the quantum technology to implement quantum information networks and quantum repeaters. A more fundamental goal is to enable the observation of fascinating quantum effects, such as entanglement, with distant material systems and to explore the limits of quantum coherence in complex material systems.

    Key words

    Quantum Information, Quantum optics, Quantum memory, Entanglement
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    Deco, Gustavo
    Research Professor at
    Universitat Pompeu Fabra (UPF)
    Engineering Sciences
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    Research interests

    Perceptions, memories, emotions, and everything that makes us human, demand the flexible integration of information represented and computed in a distributed manner. Normal brain functions require the integration of functionally specialized but widely distributed brain areas. The main aim of my research is to elucidate precisely the computational principles underlying higher brain functions and their breakdown in brain diseases. My research allows us to comprehend the mechanisms underlying brain functions by complementing structural and activation based analyses with dynamics. We integrate different levels of experimental investigation in cognitive neuroscience (from the operation of single neurons and neuroanatomy, neurophysiology, neuroimaging and neuropsychology to behaviour) via a unifying theoretical framework that captures the neural dynamics inherent in the computation of cognitive processes.

    Key words

    Computational, Cognitive and System Neurosciences