Institut de Salut Global Barcelona (ISGlobal)
Life & Medical Sciences
My main research area is the biology of Plasmodium vivax, a neglected human malaria parasite responsible for millions of yearly clinical cases. We are presently looking for mechanistic insights of the role of reticulocyte-derived exosomes, nanovesicles of endocytic origin, in signalling the spleen and the bone marrow to unveil molecular basis of anaemia and splenomegaly. To pursue bone marrow and spleen studies, we are implementing the usage of humanized mouse models and organs-on-chip. To use this information in novel control strategies, we are exploring the use of reticulocyte-derived exosomes as a novel vaccine against P. vivax as well as novel biomarkers of liver hypnozite asymptomatic infections. To this end, we are immortalizing cell lines and constructig POC microfluidic devices. Last, to rapidly move this field to translation, we are pursuing the development of exosome-based vaccines against infectious diseases of veterinary importance.