del Portillo Obando, Hernando A.Research Professor at
Institut de Salut Global Barcelona (ISGlobal )
Life & Medical Sciences
My main research area is the biology of Plasmodium vivax, a neglected human malaria parasite responsible for millions of yearly clinical cases. We are presently looking for mechanistic insights of the role of reticulocyte-derived exosomes, nanovesicles of endocytic origin, in signalling the spleen and the bone marrow to unveil molecular basis of anaemia and splenomegaly and to use this information in rationale vaccine development. To pursue spleen studies, we are implementing the usage of humanized mouse models and microfluidic approaches. In addition, we are exploring the use of exosomes as novel vaccines and biomarkers in vivax malaria aimed for elimination. Last, we are immortalizing human hematopoietic stem cells to develop a continuous in vitro culture system for blood stages of this malaria species, a major technological key-gap to advance studies of this neglected human malaria.