Universitat Autònoma de Barcelona (UAB)
Life & Medical Sciences
The main objective of our research group is the development of new strategies to combat infections by multidrug-resistant (MDR) bacteria, in particular of the Gram-negative (GN) group. The increasing emergence and spread of MDR pathogens constitutes at present one of the major threats to public health. The shortage of effective antimicrobials for the treatment of MDR GN infections is particularly critical as cases of pan-resistance are not uncommon. The discovery of new drug targets and modes of action (MoA), less prone to the development of resistance, has therefore become a pressing need. In parallel, the development of effective vaccines may offer a solution for high-risk population groups. Our team combines a range of computational and experimental techniques for the identification of antimicrobial-target candidates with new MoA and vaccine candidates eliciting prescribed resposes. Much of this work is done in collaboration with the group of Bacterial Molecular Genetics of IBB.