Brander, ChristianResearch Professor at
Institut de Recerca de la Sida - IrsiCaixa (IrsiCaixa )
Life & Medical Sciences
Our group's aim is to understand the cellular immunity to viral infections in the immune compromised host, including HIV infected subjects and individuals undergoing organ transplantation. Using complementary sets of immune analyses and integrated -omics approaches, we seek to identify functional correlates of relative virus control and to explore the underlying mechanisms of such virus control by the cellular immune system. A main focus lies on the definition of biomarkers of controlled HIV infection, for which we analyse samples from individuals enrolled in in-house conducted vaccine trials and our cohorts of HIV controllers, acute HIV infection and highly-exposed, seronegative individuals. To better identify and characterize virus-specific T cell responses, we have developed new ("boosted") flow cytometry tools and combine methylome and communicome analyses to assess to what degree and at what stages of HIV infection their effector function profiles are epigenetically controlled.
Key wordsHIV, cellular immunity, host genetics, viral evolution, viral immunity in solid organ transplantation