Secreted splicing variant of mammal Klotho as a medicament for cognition and behaviour impairments

M.Chillón, A.Massó, A. Bosch
Universitat Autònoma Barcelona

The invention disclose using secreted splicing variant of mammal Klotho (s-KL) as an agent for the prevention and/or treatment of cognitive and/or behaviour impairments. It also refers to gene constructs and expression vectors useful in gene therapy for the delivery of said s-KL variant to the central nervous system of a mammal, in particular a rodent or a human. Pharmaceutical compositions comprising either the protein s-KL or any gene construct for expressing the protein in the CNS are also disclosed.

Filing date: 19 Nov, 2015

Licenced date: 14 Dec, 2016

EP15195470.8

Process for quantum random number generation in a multimode laser cavity

Valerio Pruneri, Carlos Abellán, Waldimar Amaya, Morgan Wilfred Mitchell
ICFO, ICREA

A process and system for producing random numbers by means of a quantum random number generator is disclosed, comprising the steps of operating a multimode laser in a laser cavity with periodic modulatio of a net gain, and detecting the random indensity pattern produced by th the inter-mode beating occurring within the laser cavity. The numbers produced are truly random and a minimal number of elements is required for operating the system.

Filing date: 27 Oct, 2015

US 14/923,495

HUMANIZED NEUROMELANIN-CONTAINING RODENT

Miquel Vila Bover, Iria Carballo-Carbajal, Ariadna Laguna Tusest, Jordi Bové Badell, Thais Cuadros Arasa
Vall d'Hebron Institut de Recerca (VHIR)

Filing date: 15 Oct, 2015

PCT/EP2015/073909

Non-magnetic insertion probe for spectroscopic measurements

J. R. Galán-Mascarós, Cristina Sánez de Pipaón Soba, José Luis León, Agustín Camón, Javier Pérez
Institute of Chemical Research of Catalonia (ICIQ)

The present invention provides a non-magnetic insertion probe for performing spectroscopic experiments in a temperature range from 2 K to 400 K, with a spectral range from 200 to 1300 nm. The probe can work under high vacuum, under gas stream, and under high magnetic fields (> 10 T) and is useful for measurement of solid samples. It can be used in single radiation transmission mode to avoid problems of radiation back scattering. The light beam inside and outside the probe is guided by fiber optic guides. The invention comprises three main parts: an optic rod, an experimental space sealer, and a sample holder. Optic fibers guide the light through the sample space in and out of the sample holder. At least one guide is bent such that light reverses direction towards the exterior, before or after passing through the sample. Optionally, both fiber guides can be bent. The fibers enter the experimental space through the sealer and optic rod. The sealer maintains the experimental space isolated from the exterior, preventing any leakage. The optic rod guides the fibers in the direction of the sample holder and can be constructed at variable length. Further advantageous embodiments are defined in the dependent claims.

Filing date: 2 Oct, 2015

Licenced date: 12 Dec, 2017

EP15382481.8