Functionalized Enzyme-Powered Nanomotors

Samuel Sánchez, Tania Patiño Padial, Ana C. Lopes Hortelao
IBEC

The present invention provides an enzyme - powered nano motor , comprising a particle with a surface , an enzyme , and a heterologous molecule ; characterized in that the enzyme and the heterologous molecule are discontinuously attached over the whole surface of the particle . The invention also provides the nanomotor for use in therapy , diagnosis and prognosis , in particular , for the treatment of cancer . Addi tionally , the invention provides the use of the nanomotor for detecting an analyte in an isolated sample .

Filing date: 5 Dec, 2018

Licenced date: 17 Jan, 2023

US Patent App. 17/299,727

Graphene doping by thermal poling

M. Marchena, P. Mazumder, V. Pruneri

Filing date: 18 Oct, 2018

Licenced date: 18 Oct, 2018

US62/747,219

Circuit for the multiplexing and read-out of variable-resistance sensor arrays

Guimerà Brunet, Anton; Terés Terés, Lluis Antoni; Dei, Michele; Cisneros Fernández, Jose Agustín; Serra Graells, Francisco; Garrido Ariza, José Antonio
ICN2

This present innovative solution relates to an apparatus and a method for multiplexing and reading arrays of sensors whose electrical resistance is modulated by the signals to be measured. According to the innovative solution, the sensors are arranged in a bi-dimensional array so that their 10 terminals are grouped column- and row-wise. Independent voltage sources are applied to each column of the array in order to stimulate harmonic waveforms of different amplitudes, frequencies and phases. For each sensor, the corresponding column harmonic voltage waveform is mixed with the variable-resistance signal to be measured generating a modulated current 15 waveform. These modulated currents are summed row-wise and collected at the read-out circuit, either by applying a constant voltage to each row of the array or by connecting a capacitor and converting these current summations into output 20 voltage signals. Finally, the read-out circuit de-multiplexes each individual sensor signal to be measured by means of lock-in demodulation according to the frequencies and phases employed for the stimulation of each column. The proposed innovative solution does not require any switching element in 25 the array to perform the sensor multiplexing. Also, the generation of artifacts is strongly reduced thanks to its continuous-time waveform operation compared to discrete-time scanning techniques. Moreover, the use of frequency and phase lock-in demodulation during de-multiplexing strongly reduces the equivalent noise bandwidth of the overall read-out system. Furthermore, the 30 low-frequency noise contributions added by the read-out circuits can be filtered out through the appropriate selection of frequencies for each column of the array. Finally, a novel method for manufacturing the sensor array is presented. The method uses GFET transistors.

Filing date: 3 Aug, 2018

WO2020025786A1

METHODS OF QUANTIFYING LIF AND USES THEREOF

Filing date: 18 Jun, 2018