Vilardell Trench, JosepResearch Professor at
Institut de Biologia Molecular de Barcelona (CSIC - IBMB )
Life & Medical Sciences
Living systems carry on the information to reproduce. This property is subjected to Natural Selection and there are many examples of strategies to optimize storage of genetic information. However, apparently this does not hold in multicellular organisms, including us. Most our genes are repeatedly interrupted by comparatively many large, meaningless, segments, that are neatly removed before decoding the gene. This removal is done by the spliceosome, genome’s ghostwriter and possibly the most complex machine in a eukaryotic cell. Our research aims at what controls the spliceosome and how this is achieved. For this we follow a reductionist scheme with the yeast model, using molecular and computational approaches. We study the initial steps in the recognition of “meaningless” segments and their regulation. In addition, taking advantage of large datasets publicly available, we investigate how the spliceosome responds to aging, mutations, or disease, both in yeast and human cells.
Key wordsRNA splicing, genomics, gene expression, genetics, yeast, human