Institut de Recerca Biomèdica (IRB Barcelona)
Life & Medical Sciences
My interests focus on computational approaches for elucidating mutational processes that generate genetic diversity within populations and across species, with the goal of understanding mechanisms of mutagenesis and DNA repair. I am also interested in developing statistical frameworks for detecting genomic signatures of negative or positive selection, which are often challenging to distinguish from the background DNA sequence variability that results from accumulated mutations. Such novel methodologies provide opportunities to gain insight into evolution of genomes, by revealing details of the interplay between mutation and selection. The biological questions I addressed include learning about evolution of gene function and regulation, in particular related to mechanisms underlying stress resistance and disease. In addition, I am interested in distributions of genetic variants in the human germline and soma, which can reveal how DNA repair is organized along eukaryotic chromosomes.