CURRENT POSITIONS: * ICREA Professor of Life & Medical Sciences. IDIBAPS Research Institute (Barcelona) * Adjunct Visiting Professor, JG Brown Cancer Center, Univ. Louisville School of Medicine (USA) * Adjunct Lecturer, Dept. of Biomedicine. Univ. of Barcelona School of Medicine (Barcelona) RESEARCH FUNDING: * Public Agencies: European Commission / National Research Agency - Spanish Ministry of Science & Innovation / Catalan Agency for University & Research Grants (AGAUR) * Private Foundations: Leukemia Research Foundation / Duchenne Parent Project / AVON Breast Cancer Campaign / Spanish Association Against Cancer (AECC) / La Marató TV3 Foundation / Olga Torres Foundation / La Caixa Foundation / Catalan Academy of Medical & Health Sciences. OTHER WEBSITES & SOCIAL MEDIA HANDLES: IDIBAPS: https://bit.ly/3oLnMSW Twitter: @GeneRegLab
Our group studies the molecular mechanisms that regulate cell plasticity in health and disease with a particular focus on transcriptional regulation. Ongoing projects investigate gene regulation in inflammation, cancer initiation and progression, stem cell determination and differentiation, and tissue injury and regeneration. We use a wide range of technical approaches that include unique conditional transgenic mice, ex vivo culture and manipulation of normal and malignant primary cells, differentiation of human embryonic stem cells, and high-throughput techniques (e.g., RNAseq, scRNAseq, proteomics). As molecular models, we use the EMT transcription factors ZEB1 and ZEB2 which play key roles in the regulation of cell plasticity.