Rodent models obtained by knock-in of the human HER2 gene

PCT/EP2024/083236The present invention is comprised within the field of biotechnology. Particularly, the present invention relates to a novel HER2 transgenic rodent and to its use to develop a tumor model to test HER2-directed cancer therapies. Further, the invention also relates to a method for producing a rodent cell lacking the Erbb2 gene and to a method for obtaining the transgenic rodent.