Nuage Therapeutics (Nuage Tx) is a spin-off company from the Institute for Research in Biomedicine (IRB Barcelona) and ICREA, that stemmed from the Laboratory of Molecular Biophysics lead by Dr. Xavier Salvatella. The company was incorporated on 29th July 2021.
The mission of Nuage Tx is to leverage biomolecular condensation and chemical biology to develop selective modulators of disordered proteins involved in challenging indications representing unmet medical needs.
Nuage Tx was founded by Xavier Salvatella, Mateusz Biesaga and Denes Hnisz, a team of scientists with complementary expertise that provide unique perspective on targeting intrinsically disordered proteins. Xavier Salvatella is an ICREA Professor and Leader of the Laboratory of Molecular Biophysics at IRB Barcelona. He is a renowned expert in intrinsically disordered proteins, biomolecular condensation and the structural properties of the transactivation domain of androgen receptor. Mateusz Biesaga is a PhD student and an MSCA fellow at the laboratory of Xavier Salvatella. He holds a degree in biomedical engineering and has expertise in assay development and validation for drug discovery. Denes Hnisz is the Leader of Precision Gene Control group at the Max Planck Institute for Molecular Genetics in Berlin (Germany). He is a prominent expert in transcriptional control, nuclear condensates and genome structure.
The first program of Nuage Tx aims to develop a potent and selective drug targeting the transactivation domain of androgen receptor to deliver a life-changing treatment to patients with castration-resistant prostate cancer. Nuage Tx is developing a proprietary Condensation Screening Assay and a Target Discovery Algorithm that will be used to identify new targets and new drug candidates. Nuage Tx aims to become a platform company with multiple assets in its pipeline.
Nuage Tx has already in-licensed a patent application from the Institute for Research in Biomedicine (IRB Barcelona) related to a proprietary in vitro condensation assay developed at Dr. Xavier Salvatella’s lab. The core intellectual property of Nuage Tx will be based on protecting the drug candidates once they reach a sufficiently advanced development stage. Other patent applications from public institutions or private entities will be in-licensed, if deemed necessary, to strengthen Nuage Tx’s patent portfolio.