de la Cruz Montserrat, Francisco Javier
Life & Medical Sciences
Vall d'Hebron Institut de Recerca (VHIR)
Phone 934893000-Ext.2687
Email xavier.delacruz@vhir.org
Department Bioinformàtica Clínica i Translacional
Address Edifici mediterrània, Pg. de la Vall d'Hebron, 129, Horta-Guinardó
Address 2 Pg. Vall d'Hebron 119-129
Postal code 08035
City Barcelona
Keywords
Computational Biology
In silico tools
Machine Learning
Artificial Intelligence
Protein Mutations
Molecular Diagnostics
Bioinformatics
Epigenetics
Systems Biology
Short biography
My career revolves around the application of in silico tools to address biological questions. My Ph.D. focused on the study of protein structure principles underlying function, work that I pursued at the National Institutes of Health (1993–1997) and University College London (1997–2000). After joining ICREA, this topic continued to dominate my activities (Parc Científic de Barcelona, 2001–2009; IBMB-CSIC, 2009–2012). However, my interests have gradually shifted toward the study of translational problems in biomedicine. In particular, in 2012 I joined the Vall d'Hebron Institute of Research (VHIR) to enhance the applicability of our work on the pathogenicity of genetic variants, bringing it closer to healthcare stakeholders. This research earned our group consistently top-ranking positions across three consecutive editions of the prestigious CAGI contest (CAGI 5, 6, and 7), establishing us as an international reference in the field.