I became interested in organ regeneration and stem cells during my master (2001) and European PhD training (2006). The same year I got a Postdoctoral fellowship from the Fundaçao para a Ciência e Tecnología (Portugal). In 2007 I was hired as a post-doctoral researcher at the Hospital of Santa Creu i Sant Pau in Barcelona. In 2008 I moved to the Center of Regenerative Medicine of Barcelona (CMRB), under the direction of Dr. Juan Carlos Izpsiúa supported by a Juan de la Cierva fellowship. In 2014 my research in the fields of organoid generation (first work on the generation of kidney organoids highlighted in Science as one of the 10 Breacktrhoughs of 2013) and regenerative medicine was recognized by the prestigious ERC supporting my proposal ERC-StG REGMAMKID. In 2015 I got a Ramon y Cajal (100/100 points, Biomedicine) until January 2019 when I became ICREA Senior Professor.
My work is focused in understanding the molecular mechanisms leading to organ regeneration together with the development of basic knowledge in the field of pluripotent stem cells (PSCs) for regenerative medicine. My participation in the first work describing kidney organoids from induced PSCs (iPSCs) was picked by Science as runner-up for the Breakthrough of the Year 2013. My fascination towards organ regeneration allowed me to pioneer work on heart regeneration. Being aware of the importance to provide real solutions for human health, we have also pioneered the fabrication of cardiac grafts for personalized medicine. My motivation to develop cutting-edge technology for organ regeneration allowed us to take advantage from 3D bioprinting and tissue engineering to fabricate, for the first time, human renal constructs using kidney organoids and decellularized tissue. My expertise in some of these topics was recognized with the prestigious ERC-Starting grant in 2014. I received a Ramon y Cajal Fellowship (first ranked candidate, 100/100 points, 2015). I established as PI first at the CMRB (2012-14), combining my tasks as scientist with those of Deputy Director. I became Junior Group Leader (2015) at IBEC. I received 5.2 M€ in funded projects. I have published > 58 papers mostly belonging to the first decile of their respective fields), including journals as Cell, Cell Stem Cell, Materials Today, among others, and 6 book chapters receiving about 2800 citations (Scopus). My h-index is 28. I am scientific reviewer in journals and international agencies (FWO, ERC, ANRS, SNSF and MRC). I gave >100 invited talks and participated in more than 200 outreach activities. I am also devoted to translating my findings into the clinics relaying on collaborations with world-recognized clinicians and basic collaborators in UK, France, US, CH, Singapore, Luxembourg, Japan, Saudi Arabia, Italy and Spain.
Key wordsRegenerative Medicine, Pluripotent Stem Cells, Genome Editing, Regeneration