Tartaglia, Gian Gaetano
Life & Medical Sciences
* 2020 Elected Member Academia Europaea * 2020 ERC Grant * 2018 Full Professor of Biochemistry * 2014 ICREA Research Professor * 2013 ERC Grant * 2010 - Group Leader, Bioinformatics and Genomics Program, Centre for Genomic Regulation, Barcelona (Spain) * 2011 - Clare Hall Life Member, University of Cambridge (UK) * 2005-2010 - Postdoctoral Fellow, Clare Hall College, Chemistry Department, University of Cambridge (UK) * 2001-2005 - PhD, Biochemistry Department, University of Zurich, Zurich (CH) * 1996-2000 - MPhil Theoretical Physics, Statistical Mechanics, University la Sapienza, Rome (Italy)
Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders. My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS). We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins. One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.