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Engineering Sciences

Antioxidant-producing strain

AUTORS

Güell Cargol, Marc (UPF)

The present invention relates to the field of medicine, in particular to an antioxidant-producing strain able to rescue keratinocytes from oxidative stress, preferably UB-induced oxidative stress.The skin is the largest organ in the human body. Beyond its function as a barrier against pathogens or environmental factors, the skin holds relevant physiological functions such as heat regulation or immune surveillance. At the same time, it represents a crucial determiant of our physical appearance and social contact. More than 3000 different conditions affect the skin, with almost one third of the world's population lavin at least one. These diseases have a significant impact on patients quality of life, ranging from life-threatenin (malignant melanoma) to chroni and socially imparing conditions (psoriasis, atopic dermatits or acne). Environmental factors also influence skin health. For instance, excessive UV exosure causes premature ageing and skin cancer. Current treatments against the most frequent chronic skin conditions such as AD or psoriasis focus on symptom control and often cause side effects. Novel treatments that target the underlying immune components of these diseases are effective, but they pose a significant economic burden in nationa healthcare systems.