Institut de Ciències Fotòniques (ICFO)
Engineering Sciences
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Research interests
Our research focuses on the development of advanced optical techniques to the study of biological processes at the single molecular level on living cells. We focus on the development and application of different forms of super-resolution microscopy as well as nanophotonic-based approaches to reach spatial resolutions around 10nm on intact cells. Fluorescence correlation spectroscopy in ultraconfined volumes, and multi-color single particle tracking are exploited to gain access to dynamic processes down to the microsecond time resolution. Using these combined approaches, we aim at understanding how spatiotemporal compartmentalization of biomolecules inside cells regulates and control cell function. This fundamental question has important implications for health and disease, touching the fields of cell biology and immunology. Most recent research focuses on the fields of nano-mechanobiology at the level of the cell membrane and liquid-liquid phase separation in living nuclei.
