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Vilardell Trench, Josep
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ICREA Research Professor at CSIC - IBMB (Institut de Biologia Molecular de Barcelona). Life & Medical Sciences
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1990: PhD. in Biochemistry by the Universitat Autònoma de Barcelona (Spain)
1991: Albert Einstein College of Medicine, New York (USA)
2002: Group Leader at the Center of Genomic Regulation, Barcelona (Spain)
2009: ICREA Research Professor at the Molecular Biology Institute, Barcelona
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Research Interests
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My research is centered on the molecular mechanisms of control of pre-mRNA splicing. We use yeast as a model to understand regulatory strategies of human cells. We focus on control of spliceosome assembly, regulation of 3' splice site (SS) selection, and the link between disease and splicing control of ribosome biogenesis. The first point is pursued studying how binding of a factor to a transcript stalls spliceosome assembly by blocking a rearrangement, (chromatin is also involved). For the control of 3'SS definition, we examine its selection both globally and in particular transcripts. We have been able to model the spliceosome requirements for 3'SS selection, and to explain all but one yeast introns. We are now testing this model in human cells, where 3'SS selection in many introns remains obscure. In addition, to investigate how changes in the splicing of ribosomal protein transcripts relate to disease, we are performing bioinformatics analyses of RNA-Seq data from cancer cells.
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KeyWords
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RNA splicing, genomics, gene expression, genetics, yeast
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