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Usón Finkenzeller, Isabel
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ICREA Research Professor at CSIC - IBMB (Institut de Biologia Molecular de Barcelona). Life & Medical Sciences
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Chemistry degree in 1987, University of Zaragoza, Dr. Rer. Nat. University of Zaragoza in 1992, Product Research Scientist at the European Research Center in Brussels with Procter & Gamble for 15 months. Moved for a HCM postdoc at the University of Göttingen (Germany) and stayed for an Habilitation (German Higher Doctorate) at the chemistry faculty (1996-2001) with Prof. Sheldrick, and as C2 leading an independent research group. Moved to Barcelona in September 2003 joining the IBMB-CSIC as ICREA Research Professor.
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Research Interests
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Development of computational methods in macromolecular crystallography:
Crystallography allows us to see with our own eyes the main players in biological processes, even in functional complexes: we can see how molecules work. Nevertheless, this structural model cannot be directly calculated from the experimental data as we cannot measure the phases of the diffracted X-ray beams. Pushing the limits to solve this “phase problem” is the main aim of my research. Our program ARCIMBOLDO, downloaded by over 300 laboratories worldwide has allowed to phase ab Initio equal atom structures over twice as large and at resolutions of average, rather than exceptional experimental quality than previous methods.
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KeyWords
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Crystallography, phasing, refinement, computational methods, problem structures
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