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Sharpe, James
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ICREA Research Professor at CRG (Centre de Regulació Genòmica). Life & Medical Sciences
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1997: PhD MRC National Institute for Medical Research at Mill Hill, London (UK). "Cis-regulatory mechanisms of the Hox genes in mouse development". Lab of Dr. Robb Krumlauf.
1997-1998: Postdoc on Xenopus development, University of Chile.
1998: MRC Human Genetics Unit, Edinburgh. Postdoc on computational approaches to study mouse limb development.
2001: Development of a 3D optical imaging technique and introduction of the term "Optical Projection Tomography", commercialised under the name Bioptonics.
2003: Group Leader in Edinburgh.
2006: Senior Group Leader at the Centre de Regulació Genòmica, Barcelona (Spain).
2011: Acting Coordinator of the EMBL-CRG Systems Biology Program.
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Research Interests
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The physical complexity of a human being is truly astounding. The goal of my lab is to develop new imaging and computational methods to improve our understanding of how a carefully-organised structure like the vertebrate limb is created during embryo development. We are combining various systems biology approaches to integrate data on cell activities and gene networks into a realistic 4D computer simulation of the process.
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KeyWords
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Systems Biology, Optical Projection Tomography (OPT), 3D Imaging, Computational Biology, Gene Regulatory Networks, Biomechanics
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