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Rodriguez Nebreda, Angel
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ICREA Research Professor at IRB (Institut de Recerca Biomèdica de Barcelona). Life & Medical Sciences
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Angel R. Nebreda obtained his PhD in Biochemistry and Molecular Biology at the University of Salamanca (Spain) and then worked as a postdoc at the National Institutes of Health in Bethesda (USA), and the Cancer Research-UK Clare Hall Laboratories in South Mimms (UK), with Tim Hunt. In 1995, he started his own group at the European Molecular Biology Laboratory in Heidelberg (Germany) where he worked for 9 years and then moved to the newly created Centro Nacional de Investigaciones Oncológicas in Madrid (Spain). He is currently an ICREA Research Professor at the Institute for Research in Biomedicine, in Barcelona (Spain). His research interests focus on signal transduction mechanisms (MAPKs, CDKs) in cell proliferation, differentiation and survival, particularly in relation to cancer. He was elected EMBO member in 2003 and is Editor of FEBS Letters and the Biochemical Journal.
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Research Interests
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We are investigating molecular mechanisms of tumorigenesis, specially regarding how the p38 MAPK signalling pathway regulates cell viability, proliferation and invasion, using a combination of biochemical approaches and studies in human cancer cell lines. An important question is how the rewiring of this signalling pathway during malignant cell transformation contributes to the ability of tumor cells to bypass normal controls. Moreover, we use genetically modified mouse models that allow the inactivation of this pathway in a regulated and tissue-specific manner to investigate physiological functions of p38 MAPKs as well as their role in lung, colon and breast cancer. We also use mouse models to investigate the connection between inflammation and tumorigenesis. Finally, we are studying the regulation and functions of a new family of proteins named RINGO that can activate the cell cycle kinases CDK1 and CDK2.
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Key Words
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p38 MAPK, signal transduction, cancer, CDK regulation, oocyte meiotic maturation
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