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Pujol Onofre, Aurora
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ICREA Research Professor at IDIBELL (Institut d'Investigació Biomèdica de Bellvitge). Life & Medical Sciences
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After receiving her M.D from the Autonomous University of Barcelona Medical School (Spain), Aurora Pujol moved to the laboratory of Applied Tumor Virology (Prof Rommelaere) at the German Cancer Research Center (DKFZ), in Heidelberg, where she obtained her Ph.D in Molecular and Cellular Biology from the University of Heidelberg. From 1998 to 2001 she worked as postdoctoral researcher at the laboratory of Human Genetics of the IGBMC, Strasbourg, France, lead by Prof Jean Louis Mandel, where she generated and characterized mouse models for a rare neurometabolic disorder, X-linked adrenoleukodystrophy (X-ALD). In 2002, she obtained a position as Consultant in Medical Genetics at the Louis Pasteur University Hospital, and combined genetic counselling with a position as Junior Group Leader at the IGBMC to continue her research. In January 2005, she moved back to Barcelona as an ICREA Research Professor.
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Research Interests
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Our lab is committed to find a cure for a rare and fatal demyelinating, neurometabolic disorder called adrenoleukodystrophy. We are using mouse models for molecular dissection of neuropathogenesis leading to disease and for assaying therapeutic strategies, with a clear translational aim. We are focusing on oxidative stress and mitochondria depletion as early events on the pathogenic cascade.
Moreover, by means of an integrative genomics approach, we are exploring the evolutionary origin of peroxisomes and their related metabolic routes. The derived knowledge might contribute to unravelling the role of this poorly studied organelle in ageing, neurodegenerative diseases, and in rare metabolic syndromes of yet unknown origin.
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KeyWords
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Neurodegenerative diseases, leukodystrophies, rare diseases, , mouse models, peroxisomes, comparative genomics
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