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Postigo, Antonio
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ICREA Research Professor at IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer). Life & Medical Sciences
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* ICREA Research Professor. Group of Regulation of Gene Expression. Dept of Oncology and Hematology. IDIBAPS Research Institute. Barcelona. Spain
* Professor of Cancer Biology. James Graham Brown Cancer Center. Univ of Louisville. KY. USA
* Graduated in Medicine (M.D.) (Univ Complutense, Madrid, Spain)
* Ph.D. in Biochemistry and Molecular Biology (Univ Autonoma, Madrid, Spain). Expression and function of cell adhesion molecules during lymphoid activation and differentiation
* Postdoctoral & independent group in the US (Washington Univ, USA). Regulation of gene expression during cell differentiation and cancer by the ZEB family of transcription factors
* Independent group as ICREA: Regulation of gene expression during cell differentiation and cancer by the ZEB family of transcription factors
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Research Interests
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The group investigates regulation of gene expression, mainly at the transcriptional level, during cell differentiation and oncogenic transformation. To that purpose, for the last 15 years we have used as molecular model the ZEB family of factors and studied their expression and function in different tissues during normal cell differentiation, tumorigenesis and metastasis. ZEB1 (also known as delta-EF1, zfhx1a) and ZEB2 (SIP1, zfhx1b) are transcription factors that regulate key regulatory genes during development, cell differentiation and cancer. Recent studies have involved both proteins in the maintenance of a normal and cancer stem cell phenotype as well as in the invasive behavior of tumors.
Ongoing work in the laboratory aims at understanding how ZEB1 and ZEB2 regulate target genes during stem cell determination, cell differentiation, oncogenic transformation and metastasis using cell systems and in vivo models.
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KeyWords
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Transcriptional Repression / Cancer / Cell differentiation / Tumor invasiveness / Metastasis / ZEB proteins (ZEB1, ZEB2)
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