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Malhotra, Vivek
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ICREA Research Professor at CRG (Centre de Regulació Genòmica). Life & Medical Sciences
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Education
B.Sc:Biochemistry Department, Stirling University (1978 -1982).
D.Phil:Biochemistry Department, Oxford University (1982 -1985).
Post-doctoral Fellow:Biochemistry Department, Stanford University (1985 -1990).
Research and professional experience
7/1/90-7/1/95: Assistant Professor, UC San Diego, Biology Department.
7/1/95-7/1/99: Associate Professor (tenured), UC San Diego, Biology Department.
7/1/99 – 10/31/2008: Professor, UC San Diego, Cell and Developmental Biology Department.
7/1/98 - 7/1/2003: Adjunct Member, Mario Negri Sud Research Institute, Italy.
1999 – 2000: ICREA Visiting Scientist, University of Barcelona, Spain.
11/1/2007-Chair, Cell and Developmental Biology, CRG, Spain.
Awards and Honors
Secretary, Oxford University Biochemical Society (1982-1984); Pirie-Reid Scholar, Oxford University (1982-1985); Damon-Runyon Walter-Winchell Post-doctoral Fellow, Stanford University (1985-1987); American Cancer Society (California Division)
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Research Interests
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We want to understand the mechanism of transport carrier formation from the Golgi apparatus. Our genome wide screens have revealed new genes required for constitutive and regulated protein secretion. These components are being characterized for their specific roles. We have recently found that a Golgi associated protein called GRASP is required for secretion of proteins lacking a conventional signal sequence. We are using in vitro approaches and mouse models to understand the mechanism and physiological significance of unconventional (meaning without entering the ER-Golgi pathway) secretion. Golgi membranes undergo extensive fragmentation during mitosis in mammalian cells. We have found that this fragmentation begins early in G2, which if blocked, prevents the entry of cells into mitosis. Our aim is to understand the molecular mechanism of this Golgi organization specific cell cycle checkpoint.
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KeyWords
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Protein secretion, transport carriers, unconventional secretion, Biogenesis of Golgi membranes.
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