| |
|
|
Macías Hernández, María Jesús
|
|
|
ICREA Research Professor at IRB (Institut de Recerca Biomèdica de Barcelona). Life & Medical Sciences
|
Since 2002 at the Institute for Research in Biomedicine, IRB Barcelona working as ICREA Research Professor in the structural and computational programme as principal investigator of the protein NMR group.
Past positions: Staff Scientist at the EMBL (NMR group) Heidelberg, Germany. 1998- 2002. Post Doctoral position at the EMBL Heidelberg, Germany in the group of Prof. Dr. H. Oschkinat, 1993-1998.
PhD Degree: PhD in Organic Chemistry, Salamanca University (Spain) 1993, supervised by Prof. M. Grande
Research Fields: Structural determination of biomolecules in solution NMR
Current Research:
-Structure determination of protein domains and complexes involved in splicing and signaling.
-Protein folding and stability.
-Software development to facilitate the assignment of NMR data and the determination of protein structures in solution.
|
Research Interests
|
|
Inter- and Intra-cellular communication is fundamental for the existence and survival of multicellular organisms and defects in these processes often lead to disease. At the molecular level, the basis for the transmission of information is the organization of complex networks, many of which are based on protein-protein interactions. In many instances these interactions are tightly regulated by phosphorylation. Understanding these interactions requires efforts that combine the atomic resolution that structures can provide with other functional approaches. Since protein phosphorylation normally implies conformational changes, NMR is a powerful technique to perform the structural studies.
Thus, we focused our research on elucidating the mechanisms of phosphorylation and the role behind its distinct functions in Smad-binding proteins as Smurf, Nedd4L and YAP, applying Nuclear Magnetic Resonance spectroscopy in conjunction with other biophysical and biomolecular techniques.
|
| |
KeyWords
|
|
|
Structural Biology
Protein structure
Nuclear Magnetic Resonance
|
| |
|