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Gomis, Roger
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ICREA Researcher at IRB (Institut de Recerca Biomèdica de Barcelona). Life & Medical Sciences
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Dr. Roger Gomis is an ICREA researcher and a member of the Oncology Program at the Institute for Research in Biomedicine, Barcelona. He received his Ph.D. degree in biochemistry from the University of Barcelona in 2002, and was a postdoctoral fellow at Memorial Sloan-Kettering Cancer Center in Prof. Joan Massagué’s laboratory. In 2007, he assumed his current position.
Dr. Roger Gomis is interested in how growth factors, signaling pathways, and gene expression programs control normal cell behavior and cancer cell metastasis. Combining cell biology, biochemistry and genetics, he delineated the organization of the TGFb response in human epithelial cells, and defined a set of genes whose activation by TGFb requires the functional and physical cooperation of FoxO transcription factors and Smad signal transducers. These findings led Dr.Gomis to unravel how breast cancer cells are refractory to TGFß mediated growth arrest, leading to further tumor progression and metastasis.
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Research Interests
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Intricate signalling networks control cell division, differentiation, movement, organization and death. Cancer cells disobey these signals during tumour progression and metastasis, which is the final step in 90% of all fatal solid tumours. Metastasis is therefore a grave public health problem and consequently a field of considerable pharmaceutical interest. A major research focus of our group is to identify and understand the genes and functions that allow tumor cells to achieve metastatic colonization of vital organs.
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KeyWords
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Metastasis, Cancer, Cell Cycle, TGFbeta, MYC
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