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de la Cruz Montserrat, Francisco Javier
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ICREA Research Professor at CSIC - IBMB (Institut de Biologia Molecular de Barcelona). Life & Medical Sciences
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Since I started my Ph.D. in biology I have been deeply involved in the computational approach to biological problems. I followed this research line during my thesis, focusing in the study of protein structure. Subsequently, and during my stay at the NIH I pursued this research line while starting to combine it with function-structure studies. This lead me to concentrate in the determinants of function and what is function at higher levels. This I did during my post-doctoral stay at the UCL, and constitutes the core of my research career as an independent scientist since I arrived at the IRB-PCB. There I also started to approach function from another level, considering how proteome variability originated by alternative splicing may modulate our original view of protein function. In 2009 I have moved to the IBMB-CSIC were I plan to pursue my research in this area, while opening a new research line in the bioinformatics study of epigenetic regulation of gene expression.
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Research Interest
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The main research goal in my group is to explore and try to understand the molecular basis of biological processes that belong to different levels of the biological hierarchy, for example mendelian diseases (high-level process), alternative splicing (low-level process), molecular basis of epigenetic regulation of gene expression (low-level process), etc. Our approach is completely theoretical, as is based on the processing of large amounts of heterogeneous information using only computers and statistics.
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KeyWords
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Bioinformatics, Computational Biology, Systems Biology, Protein Mutations, Alternative Splicing, Epigenetics, Allosteric regulation
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ERC Codes
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Genetics, genomics, bioinformatics & systems biology, Molecular biology & interactions
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