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de la Cruz Montserrat, Francisco Javier
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ICREA Research Professor at CSIC - IBMB (Institut de Biologia Molecular de Barcelona). Life & Medical Sciences
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Since I started working in science I have been involved in the computational approach to biological problems. I entered this field during my Ph.D., focusing on the study of protein structure. I subsequently moved to the NIH (Bethesda) in 1993 and then to the UCL (London) in 1997, where I continued working on protein structure analysis. During these years I developed a growing interest in the function-structure relationship. This field constituted the core of my starting career as an independent scientist when I joined the IRB-PCB, after a short stay at the UB (Barcelona). There I worked in the study of proteome variability sources and, in particular, in the study of alternative splicing, which led me to gene expression regulatory processes. Then, in 2009 I moved to the IBMB-CSIC (Barcelona) where I started working in epigenetic processes and in the regulatory properties of alternative splicing.
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Research Interests
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Our main research goal is to understand the molecular basis of biological processes that belong to different levels of the biological hierarchy: mendelian diseases, alternative splicing, epigenetic regulation of gene expression, etc. Our approach is theoretical, and is based on the processing of large amounts of heterogeneous information using only computers and statistics.
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KeyWords
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Bioinformatics, Computational Biology, Systems Biology, Protein Mutations, Alternative Splicing, Epigenetics, Allosteric regulation
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