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Cosma, Maria Pia
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ICREA Research Professor at CRG (Centre de Regulació Genòmica). Life & Medical Sciences
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ICREA Research Professor and Senior Scientist at Centre for Genomic Regulation (CRG), Barcelona, Spain since September 2010. Honorary Associate Investigator, at CNR from 2009. From 2003 to 2010 she has been Associate Investigator at TIGEM, Naples. From 2004 to 2010 Lecturer at the European School of Molecular Medicine. From 1997-2000 she worked at IMP, Vienna, as Marie Curie Post-doctoral fellow. PhD in Cellular and Molecular Genetics, Univ. Federico II of Naples, 2000. She has been Visiting Scientist in many Universities in USA. She has given many invited talks at major international conferences and Research Institutes. She has been awarded by several prizes including: EMBO Young Investigator (YIP) in 2003, Marie Curie Excellence Award in 2005. She received the honor of Order of Merit of the Italian Republic; grade: knight in 2007. She is ERC stGrant awardee, 2009 and HFSP Grant awardee, 2010. She has been elected EMBO Member 2010.
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Research Interests
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Whether reprogramming can occur in vivo in higher vertebrates and what the molecular mechanisms and genes driving reprogramming are remain to be defined. We have recently shown that activation of the Wnt/ß-catenin signalling pathway enhances reprogramming of somatic cells after their fusion with ESCs. Remarkably, the activation of this signalling pathway also controls regeneration in response to damage in lower and higher vertebrates; furthermore, cell fusion is one possible mechanism of regeneration in vertebrates. Our main goal is to determine whether in mice activation of Wnt/ß-catenin signalling controls tissue regeneration by enhancing cell-fusion-mediated reprogramming.
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KeyWords
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stem cell, reprogramming, Wnt/beta-catenin signalling, human genetic disorders, sulfatases, gene network
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