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Cerutti, Andrea
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ICREA Research Professor at IMIM (Institut Municipal d'Investigació Mèdica). Life & Medical Sciences
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Dr. Andrea Cerutti, MD, is an ICREA Research Professor at PRBB-IMIM and a Professor of Medicine at Mount Sinai School of Medicine. Dr. Cerutti has published more than 70 articles on the regulation of B cells and immunoglobulin heavy chain class switching in top-ranked journals such as Nature Immunology, Nature Reviews Immunology, Immunity, The Journal of Experimental Medicine, Blood, and The Journal of Immunology. In addition to serving in NIH study sections, Dr. Cerutti holds an I+D+I grant from the Ministerio de Ciencia e Innovación, a Marie Curie International Re-integration Grant and was recently awarded an ERC Advanced Grant from the European Research Council. He also serves as a reviewer for top immunology-medical journals such as Nature and Science and is Section Editor of The Journal of Immunology, and Associate Editor of Mucosal Immunology. Dr. Cerutti is also a member of The American Society for Clinical Investigation and The Henry Kunkel Society.
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Research Interests
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Dr. Cerutti’s laboratory studies the regulation of immunoglobulin (Ig) heavy chain class switching, a process critical for the generation of immune protection against viral and bacterial infections. By substituting IgM with IgG, IgA or IgE, class switching provides antibodies with novel effector functions. Dr. Cerutti’s aim is to dissect the mechanisms by which innate antigen receptors on epithelial cells, dendritic cells macrophages and granulocytes enhance class switching and antibody production after sensing microbial products. A better understanding of these mechanisms may lead to the development of novel or more effective vaccines against pathogens, including HIV. Dr. Cerutti’s group is also interested in the regulation and function of IgD, an enigmatic antibody isotype that arose together with IgM at the time of the emergence of the adaptive immune system. IgD is mainly produced in the upper respiratory tract and undergoes abnormal elevation in patients with autoinflammatory disorders and periodic fever, including hyper-IgD syndrome. Finally, Dr. Cerutti is interested in the mechanisms by which HIV evades protective IgG and IgA responses systemically and at mucosal sites of entry.
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KeyWords
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B cells, Immunoglobulins, Heavy Chain Class Switching, Mucosal Immunity
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