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Batlle Gómez, Eduard
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ICREA Research Professor at IRB (Institut de Recerca Biomèdica de Barcelona). Life & Medical Sciences
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Since 2004, working as ICREA Professor and coordinator of the oncology program at the Institute for Research in Biomedicine (IRB Barcelona). 1993: BSc. Universitat de Barcelona, 1994-1999: PhD fellow at Institut Municipal de Investigació Mèdica (IMIM). 1999: Associate professor of Biochemistry at the University Pompeu Fabra, Barcelona. 1999- 2000: PostDoctoral fellow at Miguel Beato’s group - Institut für Molekularbiologie und Tumorforschung, Marburg. Germany. 2000-2004: PostDoctoral Fellow at Hans Clevers Lab, Netherlands Institute for Developmental Biology, Utrecht, NL. Among other achievements, Eduard Batlle originally discovered the transcription factor Snail, which is key for cancer invasion and metastasis. More recently, he also identified a new mechanism of tumor suppression based on the activity of the EphB receptors. He has received the 2006 Debiopharm life Sciences award, the 2010 Banc de Sabadell prize for Biomedical Research and was awarded an ERC Starting grant in 2007.
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Research Interests
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The inner layer of the intestinal tube, the intestinal epithelium, is in a constant process of renewal. Hundreds of millions of terminally differentiated intestinal cells are replaced by new cells every day during the life of an adult organism. This tremendous regenerative power is ultimately sustained by a small population of intestinal stem cells. It is believed that alterations in the functioning of intestinal stem cells account for the pathophysiology of various bowel disorders. Our laboratory studies the connection between the biology of Intestinal Stem Cells and Colon Cancer. We have recently archived for the first time the isolation of stem cells of the human colonic epithelium as well as of tumor stem cells from colon cancers. We are currently analyzing the features of these two cell types with the aim of designing new therapeutic and diagnostic tools for the management of colon cancer.
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KeyWords
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Colorectal cancer, stem cells, Wnt signalling, Eph/ephrin receptors
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