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Barril Alonso, Xavier
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ICREA Research Professor at UB (Universitat de Barcelona). Experimental Sciences & Mathematics
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Xavier Barril is an ICREA Research Professor at Barcelona University’s School of Pharmacy. In 2001 he earned his Ph. D. from the University of Barcelona (Spain) for theoretical studies on the ligand-receptor molecular recognition process. He then joined the Applications Modelling team at Vernalis (Cambridge, UK). In his role as Molecular Modeller he was involved in a range of projects, mainly in the oncology area, including the discovery and optimization of Hsp90 inhibitors currently licensed to Novartis. In 2004 he was promoted to Senior Scientist. In October 2005 he was appointed ICREA Research Professor and moved back to academia. His main research interests are the chemical validation of new therapeutic targets, the integration of experimental and computational methods for drug design and the development of computational chemistry techniques. He has co-authored more than 40 publications, including research papers, reviews and book chapters, as well as a number of patents.
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Research Interest
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Combining physical chemistry, the use of computers and an intimate knowledge of the molecular processes that govern life, it is becoming possible to rationalize and expedite the discovery of new drugs. In my group we are developing new computational tools to be used in rational drug design and, at the same time, we collaborate with experimentalist to help discover and optimize molecules that may become drugs in the future.
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KeyWords
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Computer-aided drug design; Structure-based drug discovery; Validation of new therapeutic targets
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ERC Codes
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Biophysics, Chemical biology, Drug discovery, drug design, Molecular biology & interactions
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