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Aznar Benitah, Salvador
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ICREA Researcher at CRG (Centre de Regulació Genòmica). Life & Medical Sciences
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Salvador Aznar Benitah is a group leader at the Center for Genomic Regulation in Barcelona. He holds a BSc in Biochemistry at the University of McGill (Montreal, Canada), from where he moved to the Biomedical Research Institute (Madrid, Spain) to obtain a PhD in Molecular Biology under the supervision of Prof. Juan Carlos Lacal. His professional career continued at the London Research Institute (Cancer Research UK) in the laboratory of Prof. Fiona Watt where he acquired extensive knowledge on adult stem cells. As an independent researcher he now continues to study the role of adult stem cells in tissue homeostasis and cancer.
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Research Interest
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Adult stem cells ensure maintenance of the tissue and integrity in response to damage. They self-renew, are multipotential, and respond to and repair injuries.
My lab is interested in understanding molecularly how stem cells read the surrounding signals to know when to become active and to subsequently replenish the tissue. Also, we are interested in studying how the stem cells coordinate in time and space to ensure that homeostasis is maintained throughout the entire tissue. One main objective of our lab is to study how these molecular circuits controlling stem cell behavior is lost during cancer formation and aging.
Methodology: We use a combination of conditional mouse models, primary cell culture (human and mouse), live microscopy, highthroughput genomics and proteomics approaches, and basic molecular biology.
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KeyWords
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Adult Stem cells, tissue homeostasis, cancer
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ERC Codes
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Cell differentiation, physiology & dynamics, Medical and health science research, Molecular, cellular & development biology, Signal transduction
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