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Aznar Benitah, Salvador
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ICREA Research Professor at CRG (Centre de Regulació Genòmica). Life & Medical Sciences
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Salvador Aznar Benitah is a group leader at the Center for Genomic Regulation in Barcelona. He holds a BSc/MSc in Biochemistry at the University of McGill (Montreal, Canada), from where he moved to the Biomedical Research Institute (Madrid, Spain) to obtain a PhD in Molecular Biology under the supervision of Prof. Juan Carlos Lacal. His professional career continued at the London Research Institute (Cancer Research UK) in the laboratory of Prof. Fiona Watt where he acquired extensive knowledge on adult stem cells. He started as a Junior ICREA researcher at the CRG in 2007 where he studies the role of adult stem cells in tissue homeostasis and cancer. Since September 2012 he is an ICREA Research Professor.
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Research Interests
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My lab is interested in understanding how adult stem cells read the surrounding signals to know when to become active and to subsequently replenish the tissue. Adult stem cells ensure maintenance of the tissue and integrity in response to damage. They self-renew, are multipotential, and respond to and repair injuries. We are also interested in studying how stem cells are spatiotemporally coordinated to ensure that homeostasis is maintained at the level of the entire tissue. One main objective of our lab is to study how these molecular circuits controlling stem cell behavior is lost during cancer formation and ageing.
Methodology: We use a combination of conditional mouse models, primary cell culture (human and mouse), live microscopy, highthroughput genomics and proteomics approaches, and basic molecular biology.
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Key Words
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Adult Stem cells, tissue homeostasis, cancer
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